Transmission bottlenecks as determinants of virulence in rapidly evolving pathogens
نویسندگان
چکیده
منابع مشابه
Transmission bottlenecks as determinants of virulence in rapidly evolving pathogens.
Transmission bottlenecks occur in pathogen populations when only a few individual pathogens are transmitted from one infected host to another in the initiation of a new infection. Transmission bottlenecks can dramatically affect the evolution of virulence in rapidly evolving pathogens such as RNA viruses. Characterizing pathogen diversity with the quasispecies concept, we use analytical and sim...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1999
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.96.9.5095